The most fatal disease outbreaks in human history. This comprehensive dataset is meticulously compiled from verified global sources and updated regularly. Use the sorting and filtering tools to explore the data, or export it as CSV for deeper analysis. All figures are cross-referenced with authoritative international databases.
| Rank ⇵ | Pandemic ⇵ | Estimated Deaths ⇵ | Era ⇵ |
|---|---|---|---|
| 1 | Black Death (Bubonic Plague) | 1346–1353 | 75–200 Million |
| 2 | Spanish Flu (H1N1) | 1918–1920 | 17–100 Million |
| 3 | Plague of Justinian | 541–542 | 15–100 Million |
| 4 | HIV/AIDS Pandemic | 1981–Present | 40 Million+ |
| 5 | COVID-19 Pandemic | 2019–Present | 7-28 Million |
| 6 | Third Cholera Pandemic | 1852–1860 | 1 Million+ |
| 7 | Asian Flu (H2N2) | 1957–1958 | 1–4 Million |
| 8 | Hong Kong Flu (H3N2) | 1968–1969 | 1–4 Million |
| 9 | Russian Flu | 1889–1890 | 1 Million |
| 10 | Antonine Plague | 165–180 | 5 Million |
| 11 | Cocoliztli Epidemic | 1545–1548 | 5–15 Million |
| 12 | First Cholera Pandemic | 1817–1824 | 100,000+ |
| 13 | Sixth Cholera Pandemic | 1899–1923 | 800,000+ |
| 14 | Swine Flu (H1N1) | 2009–2010 | 150,000–575,000 |
| 15 | Japanese Smallpox Epidemic | 735–737 | 1 Million |
| 16 | Plague of Cyprian | 250–270 | 1 Million+ |
| 17 | Ebola Epidemic (West Africa) | 2013–2016 | 11,323 |
| 18 | Typhus Epidemic (WWI) | 1914–1918 | 3 Million |
| 19 | Plague of Moscow | 1770–1772 | 100,000 |
| 20 | Great Plague of London | 1665–1666 | 100,000 |
| 21 | Naples Plague | 1656 | 300,000 |
| 22 | Yellow Fever Epidemic (USA) | 1793 | 5,000 |
| 23 | Polio Epidemic (USA) | 1952 | 3,145 |
| 24 | Zika Virus Epidemic | 2015–2016 | Unknown |
| 25 | SARS Epidemic | 2002–2004 | 774 |